April 24, 2020
A big thank you to the NIDDK for selecting our two-year opportunity pool pilot application with the Pittsburgh O’Brien Center for funding! Over the next two years, we will be evaluating how loss of NFIB in the normal prostate results in increased proliferation of epithelial and stromal cells, immune cell infiltration, and induction of fibrosis. We will also be correlating NFIB loss in patient tissues with these histologic changes. We are excited to get this work started!
May 1, 2020
Paper published! Congratulations to Petra and all the authors! Here is a link to our paper on OPN in BPH.
April 1, 2020
New preprint! This is a nice collaborative project between the Taylor and Grabowska labs on telomere maintenance mechanisms in castration-resistant prostate cancer, led by Taylor lab graduate student Tawna Mangosh. A staggering amount of work and some really neat science! https://www.biorxiv.org/content/10.1101/2020.03.31.018846v1
March 27, 2020
New preprint! Congratulations to first and second authors Sarah and Wisam for their hard work in these studies identifying and validating drivers of enzalutamide resistance in vitro.
February 12, 2020
A big congrats to postdoc Jagpreet who was awarded an American Urological Association Research Scholar Award! This is a huge milestone for Jagpreet and a big step for the lab. A big thank you to Jagpreet’s co-mentors Dr. Scott Dehm and Dr. Lee Ponsky and the Indian American Urological Association for their support!
We would like to especially thank Dr. Kalish Kedia who helped the IAUA fund this award in 2014 in memory of his son, Anupam Ted Kedia.
December 26, 2019
New preprint! Petra found an interesting role for osteopontin in benign prostatic hyperplasia. Lots of work left to do, and Petra will continue these studies as a K12 Scholar in Madison, but this is what we know so far: https://www.biorxiv.org/content/10.1101/2019.12.23.887612v1
November 7-10, 2019
The whole lab (Sarah, Jagpreet, and Wisam), plus alumna Petra and unofficial lab member Tawna, headed out to New Orleans for the annual fall meeting. It was a great meeting with awesome science, great food, and a fun city. It is always a joy to meet so many people involved in basic urology research!
September 1, 2019
Updates from the PI
Things on the PI front will be busy this fall as well. Aside from several grant submissions, I have a couple exciting events coming up. In October, I will be attending the AUA Early Career Investigator Workshop. This time I am attending as a speaker and presenting “How to Start a Lab as a Junior Faculty” and “Negotiating the Unique Challenges of MD vs PhD Research Careers”, along with Peter Clark, MD. I am really looking forward to meeting the next generation of urology researchers, so if you have a trainee attending, be sure to put us in touch. I am also thrilled to participate in my first NIH study section as an early career reviewer. My experience reviewing for the DOD Prostate Cancer Research Program last year has clarified my writing for Idea award applications, and I am sure this experience will do the same for my subsequent R01 applications. Here is to a busy couple of months!
September 1, 2019
Updates from the Team
And just like that, summer is over. It is going to be a busy fall for the team. We have a paper to revise, another paper to write up, and plenty of grants going in to keep us busy. Jagpreet will be submitting an American Urological Association/Urology Care Foundation Research Scholar Award in a couple of days. In October, he will be attending the Early Career Investigator Workshop to learn about applying for grants and running a research lab. Meanwhile, Sarah will be busy with classes. This includes a course she designed herself on therapeutic resistance in prostate cancer. This is also the year of her qualifying exams, so best of luck to her during this stressful time. Finally, Wisam is working to complete his master’s while he works as a technician in the lab. He will be completing a smaller project as part of his Capstone. Wisam will be applying to graduate school in the fall, so be on the lookout for his applications! In former lab member news, Petra is wrapping up her OPN paper, and we will be submitting it soon, so stay tuned for a pre-print! We also have a couple collaborative projects in bladder cancer and telomere maintenance that are percolating through, and we hope to write up by the end of the year! Check back here for more exciting news.
August 30, 2019
The 2019 annual fall Society of Basic Urologic Research meeting in New Orleans is rapidly approaching. This last week, the lab and affiliated members submitted five abstracts! Some projects are wrapping up, and others are just becoming super interesting. The team is very much looking forward to sharing them with the urology research community. Fingers crossed some of these are picked for travel awards and/or podium presentations!
August 4-9, 2019
I attended the Hormone-Dependent Cancers Gordon Research Conference in Sunday River, Maine to share some of our exciting new data during the poster session! This is my second time at this conference, and it did not disappoint. I enjoyed catching up with some old friends and ironing out new grant ideas.
July 20, 2019
Happy to announce that I will be this year’s Society of Basic Urologic Research liaison to the American Urological Association’s Advocacy Summit in Washington, DC in March 2020. I am thrilled to be part of this event and am looking forward to advocating for urology research funding. I hope that if you are involved in urology research, you will consider joining the summit!
July 15, 2019
Summer is halfway done and the lab is in full swing! We have a paper under review, first drafts being written, figures being finalized, and exciting experiments ongoing. We hope that the end of summer will bring us another pre-print and five submitted abstracts for this year’s Society of Basic Urologic Research meeting in November. So far, so good!
May 31, 2019
Today is Petra's last day! She has done a huge amount of work in the past six (six-and-a-half, she keeps reminding me) months. On Monday, she will be starting her position as a K12 Scholar at the University of Wisconsin, Madison Department of Urology. I am super grateful for all the hard work Petra has done while in my lab and very excited for this next step in her academic career. We have a couple more experiments to finish, but be on the lookout for a manuscript describing some of her work by fall!
May 3-6, 2019
Petra and I are attended the annual American Urological Association meeting in Chicago. It was wonderful to catch up with some old friends, make some new ones, and moderate some poster sessions.
MP06: Benign Prostatic Hyperplasia: Basic Research & Pathophysiology (Friday 7-9AM, Petra)
MP68: Prostate Cancer: Basic Research & Pathophysiology II (Sunday, 3:30-5:30PM, me)
April 26, 2019
For the third year in a row, the Grabowska lab participated in DNA Day. Petra, Sarah, Wisam, and Jagpreet headed to a local middle school to teach some future scientists about DNA and perform a DNA extraction from strawberries. This is a wonderful community event, and I am glad the Department of Genetics and CWRU SOM continue to organize and support it!
April 17, 2019
Big news! After lots of hard work and furious grant writing, Petra has been awarded a K12 Scholar position through the UW-Madison Multidisciplinary K12 Urologic Research Career Development Program. This is a tremendous opportunity for Petra and I am so excited for her to continue to develop her own research program at one of the best places in the country for benign urology research.
April 12, 2019
Exciting news on the social media front! The American Urological Association has identified me as someone to follow on Twitter at our big spring meeting in Chicago. This is a wonderful opportunity to share some of the amazing basic science that will be presented at AUA19, and I am looking forward to reaching a broader urology audience this year. Follow #AUA19 and #SBURatAUA19 on Twitter for all the latest news and events at the meeting!
March 21, 2019
It has been a busy couple of weeks for Petra! First, she has been invited to speak at the 2019 O'Brien Center Spring Symposium, "Molecular and Cellular Mechanisms of Fibrosis" at the University of Wisconsin-Madison. She has also been awarded a travel award to attend the AUA Basic Science Symposium and present some of her work. Congratulations!
November 8-11, 2018
Society of Basic Urologic Research (SBUR) Annual Meeting, Palm Springs, CA
Jagpreet and Wisam presented posters with some new data. The program was very interesting, and we had a great time hearing what is new in basic urologic research. Pictures for the website have been updated and we have plenty of new ideas to implement into our projects.
It is always wonderful to catch up with everyone too!
October 18-19, 2018
Great Lakes Nuclear Receptor Conference
I had a wonderful time attending the 8th GLNRC, hosted by the University Of Minnesota Masonic Cancer Center and presenting some new data. Always nice to hear about nuclear receptors and meet some trainees in the field. I highly recommend this meeting, as it is stellar.
November 9-12, 2017
Society of Basic Urologic Research (SBUR) Annual Meeting, Tampa, FL
We had a busy conference! I presented some of our work on networks that control benign prostatic hyperplasia development during the Friday morning session, and Wisam presented a poster Friday night. Always lovely to catch up with old science friends and make new ones.
September 28, 2017
After a rocky submission process, we've submitted our first collaborative grant to the Department of Defense Prostate Cancer Research Program. Very excited about the new collaboration with Dr. Derek Taylor's group at CWRU. We will know the outcome sometime in January. Keeping our fingers crossed!